Proteins-Peptides and Amino Acids

Our proteins, peptides and amino acids research group would be focused on design, synthesis and development of biologically active target molecules of natural and non-natural origin. Students would be exposed to the various formations of amide bonds from less to more hindered targets, and most importantly NMR (1H, 13C, DEPT, COSY, HMQC/HMBC, nOe, and Coupling Constant Calculations studies or other 2D experiments) interpretation.

Previous problems currently being or to be addressed include:

  • The synthesis of hundreds of medicinally significant molecules utilizing amide bond formation protocol for ChemRoutes and CanAm Bioresearch Inc.
  • Synthesis of the Tripeptide Boc-Gln(Trt)-Ala-Arg(Mtr)-OH for MET Inhibition.
  • Synthesis of Boc-Gln(Trt)-Ala-OH and Arg(Mtr)-OH Motifs for biological targets.
  • Critical amide bond coupling for the synthesis and characterization of korormicin derivatives which has an inhibitory activity towards the growth of marine Gram-negative bacteria.
  • Synthesis of Tryptophan-cycloalkane/aromatic motifs and their binding and interactions with biological receptors.
  • Synthesis of D-serine-alanine, cysteine-alanine and other motifs and their binding and interactions with biological receptors.