Reaction Development and Methodology

This program would be focused on developing a general synthetic plan, scheme or methodology for the various target molecules. The emphasis would be to use these strategies as building blocks to design our target molecules and other natural and non-natural products of medicinal significance.

Previous problems currently being or to be addressed include:

• To specifically and selectively deliver a hydride via syn-facial [1,2]-hydride migration in a pinacol-type rearrangement reaction and the results published in Angew. Chem. Int. Ed. 2008, 47, 8055-8058.
• Exploring the scope of a Glycal [3,3] Claisen Rearrangement. To generate the fused EF-ring bicyclic ethers of Adriatoxin (an analog of Yessotoxin), a unique glycal [3,3] Claisen rearrangement was applied to stereoselectively generate the syn 1,3-diaxial angular methyl groups as published in Angew. Chem. Int. Ed. 2008, 47, 8055-8058.
• Exploring and expanding the scope of the novel amide bond formation.